Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans

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題名:	Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans
作者:	Chiou W.F. Li S.Y. Ho L.K. Hsien M.L. Don M.J.
貢獻者:	化學系
關鍵詞:	cromakalim vasorelaxant activity ATP-sensitive K+ channels voltage-sensitive K+ channels
日期:	2002
上傳時間:	2009-12-11 09:33:09 (UTC+8)
摘要:	A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K+ channels as cromakalim, but through opening voltage-sensitive K+ channels. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
關聯:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 37 Issue: 1 Pages: 69-75
顯示於類別:	[化學系所] 期刊論文

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