Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans

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Title:	Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans
Authors:	Chiou W.F. Li S.Y. Ho L.K. Hsien M.L. Don M.J.
Contributors:	化學系
Keywords:	cromakalim vasorelaxant activity ATP-sensitive K+ channels voltage-sensitive K+ channels
Date:	2002
Issue Date:	2009-12-11 09:33:09 (UTC+8)
Abstract:	A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K+ channels as cromakalim, but through opening voltage-sensitive K+ channels. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
Relation:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 37 Issue: 1 Pages: 69-75
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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