Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans

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题名:	Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans
作者:	Chiou W.F. Li S.Y. Ho L.K. Hsien M.L. Don M.J.
贡献者:	化學系
关键词:	cromakalim vasorelaxant activity ATP-sensitive K+ channels voltage-sensitive K+ channels
日期:	2002
上传时间:	2009-12-11 09:33:09 (UTC+8)
摘要:	A series of 4-(cyclic amido)-2H-naphtho[1,2-b]pyrans related to cromakalim (1) has been prepared and their vasorelaxant activities on isolated rat thoracic aorta precontracted with phenylephrine have been evaluated. The relaxant mechanism of 3a was found not through ATP-sensitive K+ channels as cromakalim, but through opening voltage-sensitive K+ channels. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
關聯:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 37 Issue: 1 Pages: 69-75
显示于类别:	[化學系所] 期刊論文

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