資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://irlib.pccu.edu.tw/handle/987654321/48872
|
| 題名: | Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice |
| 作者: | Lu, HF (Lu, Hsu-Feng)
Lai, YH (Lai, Yu-Heng)
Huang, HC (Huang, Hsiu-Chen)
Lee, IJ (Lee, I-Jung)
Lin, LC (Lin, Lie-Chwen)
Liu, HK (Liu, Hui-Kang)
Tien, HH (Tien, Hsiao-Hsuan)
Huang, C (Huang, Cheng) |
| 貢獻者: | 化學系 |
| 關鍵詞: | diet-induced obesity
ginseng-plus-Bai-Hu-Tang
hepatic steatosis
insulin resistance
Panax ginseng |
| 日期: | 2020-03 |
| 上傳時間: | 2020-12-10 15:15:01 (UTC+8) |
| 摘要: | Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear.
Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice.
Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT.
Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. (C) 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC. |
| 關聯: | JOURNAL OF GINSENG RESEARCH 卷冊: 44 期: 2 頁數: 238-246 |
| 顯示於類別: | [化學系所] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 188 | 檢視/開啟 |
|
在CCUR中所有的資料項目都受到原著作權保護.
|
