Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice

CCUR > College of Natural Science and Engineering > College of Science > Department of Chemistry & Graduate Institute of Applied Chemistry > journal articles > Item 987654321/48872

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/48872

Title:	Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice
Authors:	Lu, HF (Lu, Hsu-Feng) Lai, YH (Lai, Yu-Heng) Huang, HC (Huang, Hsiu-Chen) Lee, IJ (Lee, I-Jung) Lin, LC (Lin, Lie-Chwen) Liu, HK (Liu, Hui-Kang) Tien, HH (Tien, Hsiao-Hsuan) Huang, C (Huang, Cheng)
Contributors:	化學系
Keywords:	diet-induced obesity ginseng-plus-Bai-Hu-Tang hepatic steatosis insulin resistance Panax ginseng
Date:	2020-03
Issue Date:	2020-12-10 15:15:01 (UTC+8)
Abstract:	Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. (C) 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
Relation:	JOURNAL OF GINSENG RESEARCH 卷冊: 44 期: 2 頁數: 238-246
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	188	View/Open

View Licence

Loading...