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請使用永久網址來引用或連結此文件:
https://irlib.pccu.edu.tw/handle/987654321/44639
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| 題名: | Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells |
| 作者: | Huang, C (Huang, Cheng)
Huang, YL (Huang, Yu-Ling)
Wang, CC (Wang, Chia-Chi)
Pan, YL (Pan, Yi-Ling)
Lai, YH (Lai, Yu-Heng)
Huang, HC (Huang, Hsiu-Chen) |
| 貢獻者: | 化學系 |
| 關鍵詞: | VITIS-THUNBERGII
RESVERATROL DERIVATIVES
SIGNALING PATHWAY
TUMOR INVASION
OLIGOSTILBENES
ROOTS
KINASE
CHEMOTHERAPY
ANTIOXIDANT
COMBINATION |
| 日期: | 2019-03-13 |
| 上傳時間: | 2019-06-25 12:37:03 (UTC+8) |
| 摘要: | Ampelopsins A and C are resveratrol oligostilbenes whose role in cancer development remains unknown. This study evaluated the antimetastatic and apoptosis-inducing properties of ampelopsins A and C in MDA-MB-231 cells. The IC50 values of ampelopsins A and C against MDA-MB-231 cells at 72 h were 38.75 +/- 4.61 and 2.71 +/- 0.21 mu M, respectively. However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. Additionally, antiproliferation effects of ampelopsin C were enhanced when combined with luteolin and chrysin compared to either two or a single agent in MDA-MB-231 cells. Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer. |
| 關聯: | J. Agric. Food Chem.2019, 67, 10, 2818-2830 |
| 顯示於類別: | [化學系所] 期刊論文
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