Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells

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Title:	Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells
Authors:	Huang, C (Huang, Cheng) Huang, YL (Huang, Yu-Ling) Wang, CC (Wang, Chia-Chi) Pan, YL (Pan, Yi-Ling) Lai, YH (Lai, Yu-Heng) Huang, HC (Huang, Hsiu-Chen)
Contributors:	化學系
Keywords:	VITIS-THUNBERGII RESVERATROL DERIVATIVES SIGNALING PATHWAY TUMOR INVASION OLIGOSTILBENES ROOTS KINASE CHEMOTHERAPY ANTIOXIDANT COMBINATION
Date:	2019-03-13
Issue Date:	2019-06-25 12:37:03 (UTC+8)
Abstract:	Ampelopsins A and C are resveratrol oligostilbenes whose role in cancer development remains unknown. This study evaluated the antimetastatic and apoptosis-inducing properties of ampelopsins A and C in MDA-MB-231 cells. The IC50 values of ampelopsins A and C against MDA-MB-231 cells at 72 h were 38.75 +/- 4.61 and 2.71 +/- 0.21 mu M, respectively. However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. Additionally, antiproliferation effects of ampelopsin C were enhanced when combined with luteolin and chrysin compared to either two or a single agent in MDA-MB-231 cells. Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer.
Relation:	J. Agric. Food Chem.2019, 67, 10, 2818-2830
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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