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| 題名: | Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction |
| 作者: | Lin, JF (Lin, Jeng-Feng)
Hsu, SY (Hsu, Shun-Yi)
Teng, MS (Teng, Ming-Sheng)
Wu, S (Wu, Semon)
Hsieh, CA (Hsieh, Chien-An)
Jang, SJ (Jang, Shih-Jung)
Liu, CJ (Liu, Chih-Jen)
Huang, HL (Huang, Hsuan-Li)
Ko, YL (Ko, Yu-Lin) |
| 貢獻者: | 生科系 |
| 關鍵詞: | Activin A
Acute myocardial infarction
Left ventricular remodeling |
| 日期: | 2016-07 |
| 上傳時間: | 2017-04-12 15:45:29 (UTC+8) |
| 摘要: | Background: Activin A levels increase in a variety of heart diseases including ST-elevation myocardial infarction (STEMI). The aim of this study is to investigate whether the level of activin A can be beneficial in predicting left ventricular remodeling, heart failure, and death in patients with ST-elevation myocardial infarction (STEMI).
Methods: We enrolled 278 patients with STEMI who had their activin A levels measured on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Thereafter, the clinical events of these patients were followed for a maximum of 3 years, including all-cause death and readmission for heart failure.
Results: During hospitalization, higher activin A level was associated with higher triglyceride level, lower left ventricular ejection fraction (LVEF), and lower left ventricular end diastolic ventricular volume index (LVEDVI) in multivariable linear regression model. During follow-up, patients with activin A levels > 129 pg/ml had significantly lower LVEF, and higher LVEDVI at 6 months. Kaplan-Meier survival curves showed that activin A level > 129 pg/ml was a predictor of all-cause death (p = 0.022), but not a predictor of heart failure (p = 0.767).
Conclusions: Activin A level > 129 pg/ml predicts worse left ventricular remodeling and all -cause death in STEMI. |
| 關聯: | ACTA CARDIOLOGICA SINICA 卷: 32 期: 4 頁碼: 420-427 |
| 顯示於類別: | [生命科學系] 期刊論文
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