Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction

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Title:	Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction
Authors:	Lin, JF (Lin, Jeng-Feng) Hsu, SY (Hsu, Shun-Yi) Teng, MS (Teng, Ming-Sheng) Wu, S (Wu, Semon) Hsieh, CA (Hsieh, Chien-An) Jang, SJ (Jang, Shih-Jung) Liu, CJ (Liu, Chih-Jen) Huang, HL (Huang, Hsuan-Li) Ko, YL (Ko, Yu-Lin)
Contributors:	生科系
Keywords:	Activin A Acute myocardial infarction Left ventricular remodeling
Date:	2016-07
Issue Date:	2017-04-12 15:45:29 (UTC+8)
Abstract:	Background: Activin A levels increase in a variety of heart diseases including ST-elevation myocardial infarction (STEMI). The aim of this study is to investigate whether the level of activin A can be beneficial in predicting left ventricular remodeling, heart failure, and death in patients with ST-elevation myocardial infarction (STEMI). Methods: We enrolled 278 patients with STEMI who had their activin A levels measured on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Thereafter, the clinical events of these patients were followed for a maximum of 3 years, including all-cause death and readmission for heart failure. Results: During hospitalization, higher activin A level was associated with higher triglyceride level, lower left ventricular ejection fraction (LVEF), and lower left ventricular end diastolic ventricular volume index (LVEDVI) in multivariable linear regression model. During follow-up, patients with activin A levels > 129 pg/ml had significantly lower LVEF, and higher LVEDVI at 6 months. Kaplan-Meier survival curves showed that activin A level > 129 pg/ml was a predictor of all-cause death (p = 0.022), but not a predictor of heart failure (p = 0.767). Conclusions: Activin A level > 129 pg/ml predicts worse left ventricular remodeling and all -cause death in STEMI.
Relation:	ACTA CARDIOLOGICA SINICA 卷: 32 期: 4 頁碼: 420-427
Appears in Collections:	[Department of Biology ] journal articles

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