Schizarin B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities

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Title:	Schizarin B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities
Authors:	Kuo YH;Li SY;Huang RL;Wu MD;Huang HC;Lee KH
Contributors:	化學系
Date:	2001
Issue Date:	2009-12-14 10:34:26 (UTC+8)
Abstract:	Bioassay-directed fractionation of ethanolic extract of Kadsura matsudai Hayata has resulted in the isolation of four novel C-18 dibenzocyclooctadiene lignans, schizarin B (1), schizarin C (2), schizarin D (3), and schizarin E (4). Schizarin B (1) showed moderate to strong activity for antihepatitis in both anti-HBsAg and anti-HBeAg assays, and 3 and 4 also were active in the latter assay. Compounds 1-4 were inactive in vitro against HIV replication in H9 lymphocytes. All new structures were elucidated using spectral analysis. Their structural elucidation by spectral and structure-activity relationships is also discussed.
Relation:	JOURNAL OF NATURAL PRODUCTS Volume: 64 Issue: 4 Pages: 487-490
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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