Large-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosides

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Title:	Large-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosides
Authors:	Lin, Chang-Ching Huang, Li-Cheng Liang, Pi-Hui Liu, Ching-Yang Lin, Chun-Cheng
Contributors:	化學系
Keywords:	acetylation LiClO4 one-pot synthesis glycosyl bromides thioglycosides
Date:	2006
Issue Date:	2009-11-20 13:25:03 (UTC+8)
Abstract:	This work describes a large-scale synthesis of per-O-acetylated mono- and disaccharides using a stoichiometric amount of acetic anhydride in the presence of LiClO4 under solvent-free conditions. The peracetylated saccharides underwent subsequent anomeric bromination and thioglycosidation in one-pot to yield synthetically valuable building blocks.
Relation:	JOURNAL OF CARBOHYDRATE CHEMISTRY Volume: 25 Issue: 4 Pages: 303-313
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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