The aim of this study was to investigate the relationship between perfectionism and interpersonal relationships, as well as the moderating role of mindfulness in the association between perfectionism and interpersonal relationships. This study employed a questionnaire survey method, targeting adults aged 20 to 64 years in Taiwan. Data were collected through online surveys distributed via social networking platforms such as META and LINE, utilizing a convenience sampling approach, resulting in 365 valid questionnaires. The study utilized three scales as measurement tools: a Perfectionism Scale, an Interpersonal Relationship Scale, and a Mindfulness Attention Awareness Scale. Data analysis was conducted using descriptive statistics and hierarchical regression analysis. The findings revealed that (1) positive perfectionism was positively related to interpersonal relationships; (2) negative perfectionism was positively related to interpersonal relationships; (3) mindfulness did not moderate the relationship between positive perfectionism and interpersonal relationships; (4) mindfulness moderated the relationship between negative perfectionism and interpersonal relationships. The theoretical and practical implications of these findings are discussed in the thesis.