People tend to take their spatial cognition and wayfinding behaviors for granted while moving about in familiar spaces or traversing regular routes (e.g., the way to work). However, when an emergency occurs, even if people evacuate from a familiar venue, they are still likely to experience unexpected and irreparable tragedy. This study conducted an on-site experiment and a survey investigation. First-person view (FPV) floor plans were adopted to develop a relevant experiment, which was then used to investigate the relationship between wayfinding behavior and two influencing factors: floor plan cognition and distance. The t-tests for the accompanying questionnaire indicated that women (31%) are better than men (5.3%) in legend recognition and men (25.5%) outperform women (7.1%) in orientation; both findings achieved significance and are consistent with the results of previous studies conducted by neuroscientists. One-way ANOVA showed that when participants read a floor plan that was difficult to understand (not FPV), they took considerably more time (153.82 s) to reach the closer staircase than those who read a floor plan that was easy to understand and headed to the farther staircase (113.40 s). The understandability of floor plans is key to affecting the public’s evacuation time.