In silico design and synthesis of N-arylalkanyl 2-naphthamides as a new class of non-purine xanthine oxidase inhibitors

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题名:	In silico design and synthesis of N-arylalkanyl 2-naphthamides as a new class of non-purine xanthine oxidase inhibitors
作者:	Ho, SL (Ho, Sheau Ling) Lin, CT (Lin, Ching-Ting) Lee, SS (Lee, Shoei-Sheng)
贡献者:	化材系
关键词:	in vitro and in vivo assay molecular docking N-arylalkanyl naphthamides synthesis xanthine oxidase inhibitor
日期:	2021-09
上传时间:	2021-04-22 10:51:30 (UTC+8)
摘要:	A series of N-arylalkanyl 2-naphthamides (Xa similar to e), which were predicted from virtual molecular docking on a built xanthine oxidase template as potential inhibitors, were synthesized. Their inhibitory activity against xanthine oxidase was assayed. Among these prepared, compounds Xb (IC50 13.6 mu M), Xc (IC50 13.1 mu M), and Xd (IC50 12.5 mu M) showed comparable inhibitory activity to allopurinol (IC50 22.1 mu M). The in vitro assay result correlated well with molecular docking scores, Delta G = -16.99, -17.66, and -17.13 Kcal/mol, respectively. On the potassium oxonate-induced hyperuricemic mice model, oral administration of Xc-Ac (40 mg/ Kg), the per-O-acetylated Xc, could reduce the blood uric acid level by 60% in comparison to the normal control group and is statistically significant (p < .01) while compared with the hyperuricemic mice group.
關聯:	DRUG DEVELOPMENT RESEARCH 卷 82, 期 6, 頁 789 - 801 September 2021
显示于类别:	[化學工程與材料工程學系暨碩士班] 期刊論文

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