文化大學機構典藏 CCUR:Item 987654321/49458
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 46833/50693 (92%)
造访人次 : 11852553      在线人数 : 486
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/49458


    题名: Combined corrected QT interval and growth differentiation factor-15 level has synergistic predictive value for long-term outcome of angiographically confirmed coronary artery disease
    作者: Yeh, KH (Yeh, Kuan-Hung)
    Chang, YT (Chang, Yao-Ting)
    Juang, JMJ (Juang, Jyh-Ming Jimmy)
    Chiang, FT (Chiang, Fu-Tien)
    Teng, MS (Teng, Ming-Sheng)
    Wu, S (Wu, Semon)
    Lin, JF (Lin, Jeng-Feng)
    Ko, YL (Ko, Yu-Lin)
    贡献者: 生科系
    日期: 2021-04
    上传时间: 2021-04-14 13:11:25 (UTC+8)
    摘要: Background The corrected QT interval (QTc) predicts prognosis for the general population and patients with coronary artery disease (CAD). Growth differentiation factor-15 (GDF-15) is a biomarker of myocardial fibrosis and left ventricular (LV) remodelling. The interaction between these two parameters is unknown.

    Subjects and methods This study included 487 patients with angiographically confirmed CAD. QTc was calculated using the Bazett formula. Multiple biochemistries and GDF-15 levels were measured. The primary endpoint was total mortality, and the secondary endpoints comprised the combination of total mortality, myocardial infarction and hospitalisation for heart failure and stroke.

    Results The mean follow-up period was 1029 +/- 343 days (5-1692 days), during which 21 patients died and 47 had secondary endpoints. ROC curve analysis for the optimal cut-off value of primary endpoint is 1.12 ng/mL for GDF-15 (AUC = 0.787, P = 9.0 x 10(-6)) and 438.5 msec for QTc (AUC = 0.698, P = .002). Utilising linear regression, QTc has a positive correlation with Log-GDF-15 (r = .216, P = 1.0 x 10(-6)). Utilising Kaplan-Meier analysis, both QTc interval and GDF-15 level are significant predictors for primary end point (P = .000194, P = 2.0 x 10(-6), respectively) and secondary endpoint (P = .00028, P = 6.15 x 10(-8), respectively). When combined these two parameters together, a significant synergistic predictive power was noted for primary and secondary endpoint (P = 2.31 x 10(-7), P = 1.26 x 10(-8), respectively). This combined strategy also showed significant correlation with the severity of CAD (P < .001).

    Conclusion In Chinese patient with angiographically confirmed CAD, a combined strategy utilising an ECG parameter (QTc) and a circulating biomarker (GDF-15) has good correlation with the severity of CAD, and improves the predictive power for total mortality
    關聯: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 文獻號碼: e14180
    显示于类别:[生命科學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML201检视/开启


    检视Licence

    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈