Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

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Title:	Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial
Authors:	Ho, CC (Ho, Chien-Chang) Chang, PS (Chang, Po-Sheng) Chen, HW (Chen, Hung-Wun) Lee, PF (Lee, Po-Fu) Chang, YC (Chang, Yun-Chi) Tseng, CY (Tseng, Ching-Yu) Lin, PT (Lin, Ping-Ting)
Contributors:	運教所
Keywords:	ubiquinone supplementation athletes glycaemia antioxidant sport nutrition
Date:	2020-09
Issue Date:	2020-11-06 14:10:42 (UTC+8)
Abstract:	The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study. Thirty-one well-trained college athletes were randomly assigned to ubiquinone (300 mg/d, n = 17) or placebo group (n = 14). The glycemic profile [fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], plasma and erythrocyte malondialdehyde (MDA), total antioxidant capacity (TAC), and ubiquinone status were measured. After supplementation, the plasma ubiquinone concentration was significantly increased (p < 0.05) and the level of erythrocyte MDA was significantly lower in the ubiquinone group than in the placebo group (p < 0.01). There was a significant correlation between white blood cell (WBC) ubiquinone and glycemic parameters [HbA1c, r = -0.46, p < 0.05; HOMA-IR, r = -0.67, p < 0.01; QUICKI, r = 0.67, p < 0.01]. In addition, athletes with higher WBC ubiquinone level (>= 0.5 nmol/g) showed higher erythrocyte TAC and QUICKI and lower HOMA-IR. In conclusion, we demonstrated that athletes may show a better antioxidant capacity with higher ubiquinone status after 12 weeks of supplementation, which may further improve glycemic control.
Relation:	ANTIOXIDANTS 卷冊: 9 期: 9 文獻號碼: 823
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

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