文化大學機構典藏 CCUR:Item 987654321/48772
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/48772


    题名: Method Standardization for Conducting Innate Color Preference Studies in Different Zebrafish Strains
    作者: Siregar, P (Siregar, Petrus)
    Juniardi, S (Juniardi, Stevhen)
    Audira, G (Audira, Gilbert)
    Lai, YH (Lai, Yu-Heng)
    Huang, JC (Huang, Jong-Chin)
    Chen, KHC (Chen, Kelvin H-C)
    Chen, JR (Chen, Jung-Ren)
    Hsiao, CD (Hsiao, Chung-Der)
    贡献者: 化學系
    关键词: zebrafish behavior
    color preferences
    toxicity assessment
    日期: 2020-08
    上传时间: 2020-11-03 10:41:52 (UTC+8)
    摘要: The zebrafish has a tetrachromatic vision that is able to distinguish ultraviolet (UV) and visible wavelengths. Recently, zebrafish color preferences have gained much attention because of the easy setup of the instrument and its usefulness to screen behavior-linked stimuli. However, several published papers dealing with zebrafish color preferences have contradicting results that underscore the importance of method standardization in this field. Different laboratories may report different results because of variations in light source, color intensity, and other parameters such as age, gender, container size, and strain of fish. In this study, we aim to standardize the color preference test in zebrafish by measuring light source position, light intensity, gender, age, animal size to space ratio, and animal strain. Our results showed that color preferences for zebrafish are affected by light position, age, strain, and social interaction of the fish, but not affected by fish gender. We validated that ethanol can significantly induce color preference alteration in zebrafish which may be related to anxiety and depression. We also explored the potential use of the optimized method to examine color preference ranking and index differences in various zebrafish strains and species, such as the tiger barb and glass catfish. In conclusion, zebrafish color preference screening is a powerful tool for high-throughput neuropharmacological applications and the standardized protocol established in this study provides a useful reference for the zebrafish research community.
    關聯: BIOMEDICINES 卷冊: 8 期: 8 文獻號碼: 271
    显示于类别:[化學系所] 期刊論文

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