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https://irlib.pccu.edu.tw/handle/987654321/41919
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| 題名: | Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke |
| 作者: | Wang, IK (Wang, I-Kuan)
Liu, CH (Liu, Chung-Hsiang)
Yen, TH (Yen, Tzung-Hai)
Jeng, JS (Jeng, Jiann-Shing)
Sung, SF (Sung, Sheng-Feng)
Huang, PH (Huang, Pai-Hao)
Li, JY (Li, Jie-Yuan)
Sun, Y (Sun, Yu)
Wei, CY (Wei, Cheng-Yu)
Lien, LM (Lien, Li-Ming)[
Tsai, IJ (Tsai, I-Ju)
Sung, FC (Sung, Fung-Chang)
Hsu, CY (Hsu, Chung Y.) |
| 貢獻者: | 運動與健康促進學系 |
| 關鍵詞: | CHRONIC KIDNEY-DISEASE
GLOMERULAR-FILTRATION-RATE
NUTRITION EXAMINATION SURVEY
EVALUATION PROGRAM KEEP
ALL-CAUSE MORTALITY
CARDIOVASCULAR-DISEASE
CLINICAL-OUTCOMES
GUIDELINES-STROKE
NATIONAL-HEALTH
US POPULATION |
| 日期: | 2018-02 |
| 上傳時間: | 2019-01-21 15:30:35 (UTC+8) |
| 摘要: | Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke.
Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: >= 90, 60-89, 30-59, 15-29, and <15 mL/min/1.73 m(2) or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level.
Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m(2) or dialysis than in patients with eGFR >= 90 mL/min/1.73 m(2) (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08-1.59) for patients with eGFR 60-89 mL/min/1.73 m(2) to 2.33 (95% CI = 1.80-3.02) for patients with eGFR <15 mL/min/1.73 m(2) or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21-1.59) for patients with eGFR 60-89 mL/min/1.73 m(2) to 2.60 (95% CI 2.18-3.10) for patients with eGFR <15 mL/min/1.73 m(2) or on dialysis, compared to patients with eGFR >= 90 mL/min/1.73 m(2).
Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship. (C) 2017 Elsevier B.V. All rights reserved. |
| 顯示於類別: | [運動與健康促進學系] 期刊論文
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