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| 題名: | Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection |
| 作者: | Hsu, WT (Hsu, Wei-Tung)
Ho, SY (Ho, Shu-Yi)
Jian, TY (Jian, Ting-Yan)
Huang, HN (Huang, Han-Ning)
Lin, YL (Lin, Yu-Ling)
Chen, CH (Chen, Chia-Hung)
Lin, TH (Lin, Tsung-Han)
Wu, MS (Wu, Ming-Shiang)
Wu, CJ (Wu, Chang-Jer)
Chan, YL (Chan, Yi-Lin)
Liao, KW (Liao, Kuang-Wen) |
| 貢獻者: | 生命科學系 |
| 關鍵詞: | GASTRIC EPITHELIAL-CELLS
HEAT-SHOCK-PROTEIN
CD4(+) CD25(+)
PEPTIC-ULCER
TGF-BETA
IN-VIVO
MICE
PROLIFERATION
INHIBITION
RESPONSES |
| 日期: | 2018-06 |
| 上傳時間: | 2019-01-17 14:51:33 (UTC+8) |
| 摘要: | Local Treg responses are involved in Helicobacter pylori-related inflammation and clinical outcomes after infection, and H. pylori-derived HSP60 (HpHSP60) is an important virulence factor associated with gastric carcinogenesis. This study to investigate the role of HpHSP60 in immunosuppression, particularly with regard to whether it could induce the production of Treg cells. For this purpose, human peripheral blood mononuclear cells (PBMCs) were treated with or without HpHSP60 in the presence of an anti-CD3 mAb to determine the effect of HpHSP60 on cell proliferation. In this report, HpHSP60 decreased the expression of CDK4 to significantly arrest the proliferation of mitogen-stimulated T-cells, which correlated with the induction of Treg cells. Moreover, monocytic cells were essential for the induction of HpHSP60-induced Treg cells via the secretion of IL-10 and TGF-beta after treatment with HpHSP60. Blockage of HpHSP60 with specific monoclonal antibodies significantly reduced the colonization of H. pylori and the expression of Treg cells in vivo. Overall, our results suggest that HpHSP60 could act on macrophages to trigger the expression of IL-10 and TGF-beta, thereby leading to an increase in Treg cells and inhibition of T-cell proliferation. |
| 關聯: | Microbial Pathogenesis卷 119, 頁 152 - 161 June 2018 |
| 顯示於類別: | [生命科學系] 期刊論文
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