Microfluidics-based hairpin resonator biosensor for biological cell detection

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题名:	Microfluidics-based hairpin resonator biosensor for biological cell detection
作者:	Liu, CF (Liu, Chia-Feng) Wang, MH (Wang, Min-Haw) Jang, LS (Jang, Ling-Sheng)
贡献者:	電機工程系
关键词:	DIELECTRIC-SPECTROSCOPY IMPEDANCE SPECTROSCOPY MICROWAVE-FREQUENCIES WAVE-GUIDE SENSOR TISSUE LINE GHZ
日期:	2018-06-15
上传时间:	2019-01-17 14:35:10 (UTC+8)
摘要:	In this work, a microwave hairpin resonator was used for the detection of biological cells fabricated and integrated with microfluidics. The biosensor was a microfluidic device constructed from polydimethylsiloxane (PDMS) and negative photoresist (SU-8) using micro-electro-mechanical-system(MEMS) technology to measure and characterize biological cells in a liquid medium. A biosensor witha high-Q dielectric resonator allowed the detection of biological cells by measuring the scattering parameter (S-parameter) responses at a resonant frequency of 2.17 GHz. Measurements and analyses of Dulbecco's modified Eagle's medium (DMEM) and B16F10 melanoma cells (musmusculus skin melanoma) were then performed to obtain the linear relationship between S-11 responses and the number of cells. A model of coupled resonators in terms of capacitances was then used to analyze the effects of DMEM and the cells. These results demonstrate the potential of hairpin resonator sensors for the analysis of biological cells. (C) 2018 Elsevier B.V. All rights reserved.
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