運動測試對第2型糖尿病患之血糖、血漿中的硝酸鹽／亞硝酸鹽與血管傳導性的影響

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题名:	運動測試對第2型糖尿病患之血糖、血漿中的硝酸鹽／亞硝酸鹽與血管傳導性的影響 Vascular Conductivity, Blood Glucose and Plasma Nitrate/Nitrite Response to Exercise Testing in Type 2 Diabetic Mellitus
作者:	郭芳娟林正常曾士婷
贡献者:	運教所
关键词:	運動糖尿病血管傳導性糖化血色素一氧化氮 Exercise Vascular conductivity Diabetes Glycosylated hemoglobin Nitric oxide
日期:	2008-04
上传时间:	2018-10-25 13:28:32 (UTC+8)
摘要:	Background and Purpose: Patients with type 2 diabetes without cardiovascular disease have a reduced exercise capacity compared with nondiabetic subjects. To assesse the impacts of acute exercise on glycemic control, vascular and plasma nitrate/nitrite reaction in type 2 diabetes mellitus (DM) patients. Methods: A total of 46 patients with type 2 DM and 13 control subjects with age, height and weight matched were studied. Based on the HbAIc levels, the DM patients were further divided into two subgroups: poor DM control (PDM, glycosylated hemoglobin (HbAlc≥8.0%) and good DM control (GDM, HbA1c＜8.0%). All patients underwent an incremental exercise test until they exceeded their 90% age-predicated maximal heart rate. Electrocardiogram (ECG) and blood pressure were measured during exercise. The vascular conductivity, plasma nitrate/nitrite and glucose concentration were measured before and immediately after exercise. Results: After exercise, the venous outflow, venous tone, and venous capacity significantly decreased from resting (p＜0.05); However, the venous resistance significantly increased from resting in all groups (p＜0.05). The pairwise comparisons revealed that the patients in the PDM group had lower levels of rest arterial inflow, venous outflow and venous capacity than the GDM group (p＜0.05). Those in the control group had the largest hyperemic arterial inflow among all groups (p＜0.05). Furthermore, the postprandial glucose level was significantly decreased and the plasma nitrate/nitrite level was increased significantly after exercise in the control group (p＜0.05) only, but unchanged in two diabetic subgroups. Conclusion: Poor metabolic control (HbAlc≥8.0%) may cause impairment of vascular regulation and glucose utilization during exercise testing.
關聯:	物理治療 33:2 2008.04[民97.04] 頁102-108
显示于类别:	[運動教練研究所] 期刊論文

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