本計畫是開發一種同時具有產生氧氣功能、磁共振造影顯影功能、及藥物 載體功能的多功能奈米複合材料(過氧化鈣/海藻膠/四氧化三鐵奈米粒子)，並以 此多功能奈米複合材料改善現有光動力治療因為腫瘤的缺氧微環境所導致的低 效率治療效果。缺氧環境會誘發腫瘤區域進行血管新生及腫瘤細胞轉移的行為， 同時它也是啟動與腫瘤細胞生長相關因子的源頭。因此本計畫利用過氧化鈣/海 藻膠/四氧化三鐵奈米複合材料產生氧氣來抑制缺氧環境進而抑制腫瘤細胞，產 生的氧氣同時可提高光動力治療產生的單氧濃度，因此可以達到比現有光動力 治療更有效率的腫瘤治療效果。另外，氧化鈣/海藻膠/四氧化三鐵奈米複合材料 可以做為磁共振造影的顯影劑以及藥物載體，分別具有分子影像與藥物傳輸功 能。本計畫所提出之改善腫瘤缺氧微環境並結合藥物載體和光動力治療的治療 策略，是一種具新穎性且有潛力的治療策略，與現有的光動力治療比較，針對 缺氧性腫瘤不僅改善了現有光動力治療所遭遇的問題與困難，更可以給予更高 效率的治療效果。
The purpose of this project is to synthesize a multifunctional nanocomplex (calcium peroxide /alginate/ Fe3O4 nanoparticles) with functions of oxygen generation, magnetic resonance images, and drug delivery and utilizing this nanocomplex to improve and enhance the therapeutic efficiency of photodynamic therapy in the hypoxia microenvironment of hypoxic tumor. Hypoxia microenvironment can induce cancer cells to produce angiogenesis and cancer cell migration. At the same time, hypoxia is also an important factor that can increase the expression of proteins which related to growth pathways of cancer cells. Thus, this project uses multifunctional nanocomplexs to generate oxygen to inhibit the hypoxic cancers. The generated oxygen also can increase the singlet oxygen concentration of photodynamic therapy, resulting in higher therapeutic efficiency as compare to current photodynamic therapy for cancer treatment. Furthermore, the calcium peroxide /alginate/ Fe3O4 nanocomplexs can be as molecular imaging probes and drug carriers. The strategy of this project which combines improvement of hypoxia microenvironment, drug delivery, and photodynamic therapy has high novelty and potential. Compared to current photodynamic therapy, calcium peroxide /alginate/ Fe3O4 nanocomplex-based photodynamic therapy not only improves the problems of current photodynamic therapy but also enhances its therapeutic efficiency.
