Voltage-gated calcium channels: Novel targets for cancer therapy

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Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/39375

Title:	Voltage-gated calcium channels: Novel targets for cancer therapy
Authors:	Phan, NN (Nam Nhut Phan) Wang, CY (Wang, Chih-Yang) Chen, CF (Chen, Chien-Fu) Sun, ZD (Sun, Zhengda) Lai, MD (Lai, Ming-Derg) Lin, YC (Lin, Yen-Chang)
Contributors:	生科所
Keywords:	voltage-gated calcium channels cancer under-expression potential biomarker meta-analysis Oncomine
Date:	2017-08
Issue Date:	2018-01-30 14:50:11 (UTC+8)
Abstract:	Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by a1 subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1-9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1-10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1-8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer.
Relation:	ONCOLOGY LETTERS 卷: 14 期: 2 頁碼: 2059-2074
Appears in Collections:	[Graduate Institute of Biotechnology ] journal articles

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