 |
English
|
正體中文
|
简体中文
|
全文筆數/總筆數 : 46867/50733 (92%)
造訪人次 : 11883080
線上人數 : 959
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://irlib.pccu.edu.tw/handle/987654321/39373
|
| 題名: | Teratogenic Effects of Topiramate in a Zebrafish Model |
| 作者: | Lai, YH (Lai, Yu-Heng)
Ding, YJ (Ding, Yu-Ju)
Moses, D (Moses, David)
Chen, YH (Chen, Yau-Hung) |
| 貢獻者: | 化學系 |
| 關鍵詞: | topiramate
ceratobranchial defect
teratology
zebrafish |
| 日期: | 2017-08 |
| 上傳時間: | 2018-01-30 14:43:22 (UTC+8) |
| 摘要: | Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis. In addition, around 23% of offspring displayed cartilage malformation in the craniofacial area, such as loss of ceratobranchial cartilages as well as impaired ceratohyal, Meckel's cartilage and ethmoid plate development. Moreover, mineralization of ceratohyal, Meckel's cartilage, and vertebrae were downregulated during bone development. Taken together, we concluded that topiramate impaired oogenesis in the maternal reproductive system, and then caused offspring cartilage malformation or bone dysplasia. |
| 關聯: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 卷: 18 期: 8 文獻號碼: 1721 |
| 顯示於類別: | [化學系所] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 280 | 檢視/開啟 |
|
在CCUR中所有的資料項目都受到原著作權保護.
|
