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https://irlib.pccu.edu.tw/handle/987654321/39351
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| 題名: | Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice |
| 作者: | Yeh, CW (Yeh, Chih-Wen)
Liu, HK (Liu, Hui-Kang)
Lin, LC (Lin, Lie-Chwen)
Liou, KT (Liou, Kou-Tong)
Huang, YC (Huang, Yung-Cheng)
Lin, CH (Lin, Chien-Hung)
Tzeng, TT (Tzeng, Tsai-Teng)
Shie, FS (Shie, Feng-Shiun)
Tsay, HJ (Tsay, Huey-Jen)
Shiao, YJ (Shiao, Young-Ji) |
| 貢獻者: | 技擊國術系 |
| 關鍵詞: | Metabolic stresses
Alzheimer's disease
Xuefu Zhuyu decoction
Amyloid plaque
Glia
Cognitive dysfunction |
| 日期: | 2017-09 |
| 上傳時間: | 2018-01-25 15:07:16 (UTC+8) |
| 摘要: | Ethnopharmacological relevance: Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic syndrome, amyloid-related pathologies and cognitive impairment in an animal model of AD with metabolic stress was investigated.
Materials and method: The animal model of AD with metabolic stress was created by administrating high-fat diet and a low-dose injection of streptozotocin prior to the appearance of senile plaques in APP/PS1 transgenic mice. The diabesity-associated metabolic changes and AD-related pathological alterations were examined.
Results: We found that XZD reduced body weight, insulin and leptin level, HOMA-IR, hepatic triglyceride, serum A(342 in the metabolic stressed AD animal. XZD also ameliorated oral glucose tolerant, A beta deposition, astrocyte and microglia activation in the vicinity of plaques, and nesting behavior in the metabolic stressed AD animal.
Conclusion: The results of this study suggest that XZD is able to reduce the peripheral metabolic stress mediated vascular hypoperfusion, neuroinflammation and AD-related pathology in APP/PSI mice. |
| 關聯: | JOURNAL OF ETHNOPHARMACOLOGY 卷: 209 頁碼: 50-61 |
| 顯示於類別: | [技擊運動暨國術學系] 期刊論文
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