Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide

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题名:	Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide
作者:	Chen, CT (Chen, Chun-Ta) Lee, CA (Lee, Chen-An) Tang, MO (Tang, Muoi) Chen, YP (Chen, Yan-Ping)
贡献者:	化材系
关键词:	Solute solubility Pyridin-4-amine Active pharmaceutical ingredient Supercritical carbon dioxide RESS
日期:	2017-03
上传时间:	2017-04-28 11:14:47 (UTC+8)
摘要:	Novel solute solubility data of pyridin-4-amine (C5H6N2, also known as 4-aminopyridine or fampridine) in supercritical carbon dioxide are measured in this study. This compound is an active pharmaceutical ingredient (API) for the treatment of neurological disorder, and the Alzheimer's disease. The solubility data at three isotherms (308.2, 318.2 and 328.2 K) are reported for pressures from 10 to 22 MPa. These solubility results are ranged from 2 x 10(5) to 2 x 10(4) mol fraction, and are confirmed as thermodynamically consistent. We further apply the rapid expansion of supercritical solution (RESS) process to micronize this API. At our optimal operation condition, the original API with a mean particle size of 532.3 +/- 236.5 mu m is micronized to 0.32 +/- 0.07 mu m. The RESS processed products are much more uniform and nearly spherical amorphous particles. Finally, an in vitro dissolution test illustrates an enhanced dissolution rate by 2.9 times for the micronized pyridin-4-amine. (C) 2017 Elsevier Ltd. All rights reserved.
關聯:	JOURNAL OF CO2 UTILIZATION 卷: 18 頁碼: 173-180
显示于类别:	[化學工程與材料工程學系暨碩士班] 期刊論文

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