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https://irlib.pccu.edu.tw/handle/987654321/35984
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| 題名: | A mechanism of low molecular weight fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage |
| 作者: | Hwang, PA (Hwang, Pai-An)
Yan, MD (Yan, Ming-De)
Kuo, KL (Kuo, Ko-Liang)
Phan, NN (Phan, Nam Nhut)
Lin, YC (Lin, Yen-Chang) |
| 貢獻者: | 生科所 |
| 關鍵詞: | Low molecular fucoidans
UVdamage
TGF beta RII
MMP genes |
| 日期: | 2017-02 |
| 上傳時間: | 2017-04-19 16:09:51 (UTC+8) |
| 摘要: | Fucoidans have been long used as a food supplement due to their diverse pharmacological effects on human health. Low molecular weight fucoidan (LF) is a common form of fucoidans that has been shown to have enhanced biological activity. In the present study, fucoidans were extracted from the brown alga Sargassum hemiphyllum and enzyme-hydrolyzed into low and high molecular weight fucoidans (HF). The skin protective effects of LF, HF, and other fucoidans derivatives against ultraviolet B (UVB) damage were determined by measuring the expression levels of matrix metalloproteinase genes encoding collagenases (MMP-1, MMP-2, MMP-8, MMP-9, MMP-13), transforming growth factor beta receptor II (TGF beta RII), and type I procollagen. The results show that LF protects against UVB damage to the skin by inhibiting UVB-induced transcription factor activator protein-1 (AP-1)-stimulated transcription of MMP genes encoding collagenases (MMP-1, MMP-8, and MMP-13) and increasing TGF beta RII mRNA levels to prevent the loss of TGF beta RII that occurs during UVB-induced collagen degradation. Moreover, this study reveals that the biological properties of fucoidans are highly dependent on the fucose content, sulfate content, and molecular weight. |
| 關聯: | JOURNAL OF APPLIED PHYCOLOGY 卷: 29 期: 1 頁碼: 521-529 |
| 顯示於類別: | [生物科技研究所 ] 期刊論文
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