Shape memory polyurethane (abbreviated as SMPU), it is a kind of heat recoverable shape memory polymer, and can be memory the shape by change temperature. That characteristic is recovery deformation by repetitive operation. Nano-silver is a antibacterial inorganic substances, when the silver particle to made to the nano-silver, it is easily to release the silver ions and to have the excellent anti-bacteria. In this study compounded nano-silver and SMPU to pad on the cotton fabric, then were analysed antibarcterical ability, softness and the wrinkle free properties. When the SMPU solutions is coated on the cotton fabric which softness of finished cotton fabrics decreased with increasing concentration of SMPU solution. The cotton fabrics treated with nano Ag/SMPU will obtain excellent antibacterial properties, but hybrided nano-Ag also result in decrease of shape memory of SMPU and wrinkle free of finished cotton fabrics.