The main purpose of this study is to simulate and analyze the ballistic resistance behavior of fragment simulating projectile (FSP) vertically (90°) penetrating through the mutual combination and multi-layer space of two macromolecular polymer composite materials. On the numerical simulating analysis, this study used an explicit method of finite element program "LS-DYNA 3D" to proceed the simulation. Simulation analysis includes the rear velocity after penetrating the target, the analysis of the target ballistic resistance of different shaped projectiles, length-diameter ratio (L/D) and spaces. The results from simulation were then compared with the experiment results verifying the correctness of the simulation. In the division of the finite element meshes, projectiles, glass fibers and kevlar fibers used 8-node 6-surface solid element to do the simulation. In the material settings, projectiles and glass fibers used plastic material model and kevlar used composite damage material model. The revised experience equation of this study can not only provide high forecast value of reliability, but also estimate the penetration of the projectile and the ballistic limit velocity V50 value from different ratio combination of multi-layer ballistic resistance materials.