文化大學機構典藏 CCUR:Item 987654321/32100
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 46833/50693 (92%)
造訪人次 : 11848445      線上人數 : 423
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於CCUR ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/32100


    題名: Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice
    作者: Chen, Hong-Jhang
    Shen, Yuh-Chiang
    Shiao, Young-Ji
    Liou, Kuo-Tong
    Hsu, Wei-Hsiang
    Hsieh, Pei-Hsuan
    Lee, Chi-Ying
    Chen, Yet-Ran
    Lin, Yun-Lian
    貢獻者: 國術系
    關鍵詞: GLYCOGEN-SYNTHASE KINASE-3-BETA
    TISSUE-PLASMINOGEN ACTIVATOR
    CHINESE MEDICINE
    ARTERY OCCLUSION
    NEURONAL DEATH
    STEM-CELLS
    MODEL
    RAT
    RECEPTOR
    INJURY
    日期: 2015-10
    上傳時間: 2016-02-26 15:03:12 (UTC+8)
    摘要: Stroke is the second-leading cause of death worldwide, and tissue plasminogen activator (TPA) is the only drug used for a limited group of stroke patients in the acute phase. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine prescription, has long been used for improving neurological functional recovery in stroke. In this study, we characterized the therapeutic effect of TPA and BHD in a cerebral ischemia/reperfusion (CIR) injury mouse model using multiplex proteomics approach. After the iTRAQ-based proteomics analysis, 1310 proteins were identified from the mouse brain with <1% false discovery rate. Among them, 877 quantitative proteins, 10.26% (90/877), 1.71% (15/877), and 2.62% (23/877) of the proteins was significantly changed in the CIR, BHD treatment, and TPA treatment, respectively. Functional categorization analysis showed that BHD treatment preserved the integrity of the blood-brain barrier (BBB) (Alb, Fga, and Trf), suppressed excitotoxicity (Grm5, Gnai, and Gdi), and enhanced energy metabolism (Bdh), thereby revealing its multiple effects on ischemic stroke mice. Moreover, the neurogenesis marker doublecortin was upregulated, and the activity of glycogen synthase kinase 3 (GSK-3) and Tau was inhibited, which represented the neuroprotective effects. However, TPA treatment deteriorated BBB breakdown. This study highlights the potential of BHD in clinical applications for ischemic stroke.
    關聯: PLOS ONE 卷: 10 期: 10 文獻號碼: e0140823
    顯示於類別:[技擊運動暨國術學系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML700檢視/開啟


    檢視Licence

    在CCUR中所有的資料項目都受到原著作權保護.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋