近年來，國人因糖尿病的死亡率逐年攀升，糖尿病在十大疾病死因排名第五，引起各界多糖尿病的預防和研究。對於藥物的治療，雖然降低了血糖卻引起更多的副作用，嚴重還可能導致病人的死亡。本研究中以樟芝的菌絲和發酵液作為樣品，將樣品萃取完冷凍乾燥後，分別以水、50%酒精、75%酒精進行萃取。
針對α-葡萄糖苷酶抑制活性、α-澱粉酶抑制活性、酵素動力學、抗氧化性:包括總多酚含量測定、DPPH清除力測定、還原力測定進行探討。
實驗結果顯示發酵液水萃物液的IC50很接近阿卡波糖的數值，且在多酚含量上也是以水萃的表現最佳，有潛力作為阿法葡萄糖苷酶的抑制劑。
Nowadays, the percentage of mortality caused by diabetes has reanked to the fifth among the top ten leading death, stimalating research on the prevention of this disease. Drug treatment to diabities , although it lowers blood sugar, may cause side effects and patient death. In this study, Antrodia mycelia and broth were used as samples , and extracted by water, 50% ethanol, 75% ethanol extraction. The inhibitory activity for alpha-glucosidase, antioxidant activity , the total polyphenol content, DPPH scavenging assay, reducing power assay .The results show that IC50 of water extraction of the fermentation broth is very close to the IC50 acarbose. The polyphenol content also show the best result .The result indicated that Antrodia broth is potential for used as alpha-glucosidase inhibitor.
