文化大學機構典藏 CCUR:Item 987654321/30584
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/30584


    题名: Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients
    作者: Wang, Chih-Yang
    Lai, Ming-Derg
    Phan, Nam Nhut
    Sun, Zhengda
    Lin, Yen-Chang
    贡献者: Grad Inst Biotechnol
    关键词: PROSTATE-CANCER
    BREAST-CANCER
    CELL-GROWTH
    EXPRESSION PROFILES
    NEUROTRANSMITTER RELEASE
    CHANNEL BLOCKERS
    OVARIAN-CANCER
    IN-VITRO
    HEMIPLEGIC MIGRAINE
    INTERNATIONAL-UNION
    日期: 2015-07
    上传时间: 2015-10-20 16:30:38 (UTC+8)
    摘要: Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and progression of cancer is still under investigation. The VGCC family consists of five members, which are L-type, N-type, T-type, R-type and P/Q type. To date, no holistic approach has been used to screen VGCC family genes in different types of cancer. We analyzed the transcript expression of VGCCs in clinical cancer tissue samples by accessing ONCOMINE (www.oncomine.org), a web-based microarray database, to perform a systematic analysis. Every member of the VGCCs was examined across 21 different types of cancer by comparing mRNA expression in cancer to that in normal tissue. A previous study showed that altered expression of mRNA in cancer tissue may play an oncogenic role and promote tumor development; therefore, in the present findings, we focus only on the overexpression of VGCCs in different types of cancer. This bioinformatics analysis revealed that different subtypes of VGCCs (CACNA1C, CACNA1D, CACNA1B, CACNA1G, and CACNA1I) are implicated in the development and progression of diverse types of cancer and show dramatic up-regulation in breast cancer. CACNA1F only showed high expression in testis cancer, whereas CACNA1A, CACNA1C, and CACNA1D were highly expressed in most types of cancer. The current analysis revealed that specific VGCCs likely play essential roles in specific types of cancer. Collectively, we identified several VGCC targets and classified them according to different cancer subtypes for prospective studies on the underlying carcinogenic mechanisms. The present findings suggest that VGCCs are possible targets for prospective investigation in cancer treatment.
    關聯: PLOS ONE 卷: 10 期: 7 文獻號碼: e0125766
    显示于类别:[生物科技研究所 ] 期刊論文

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