Effect of Swimming on the Production of Aldosterone in Rats

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題名:	Effect of Swimming on the Production of Aldosterone in Rats
作者:	Lieu, Fu-Kong Lin, Chih-Yung Wang, Paulus S. Jian, Cai-Yun Yeh, Yung-Hsing Chen, Yi-An Wang, Kai-Lee Lin, Yi-Chun Chang, Ling-Ling Wang, Guei-Jane
貢獻者:	化材系
關鍵詞:	ZONA GLOMERULOSA CELLS ANGIOTENSIN-II GRADED-EXERCISE RENIN-ACTIVITY LACTATE SECRETION BLOOD RESPONSES SODIUM CAMP
日期:	2014-10
上傳時間:	2015-01-20 10:28:26 (UTC+8)
摘要:	It has been demonstrated that exercise is one of the stresses known to increase the aldosterone secretion. Both potassium and angiotensin II (Ang II) levels are shown to be correlated with aldosterone production during exercise, but the mechanism is still unclear. In an in vivo study, male rats were catheterized via right jugular vein (RJV), and divided into four groups namely water immersion, swimming, lactate infusion (13 mg/kg/min) and pyruvate infusion (13 mg/kg/min) groups. Each group was treated for 10 min. Blood samples were collected at 0, 10, 15, 30, 60 and 120 min from RJV after administration. In an in vitro study, rat zona glomerulosa (ZG) cells were challenged by lactate (1-10 mM) in the presence or absence of Ang II (10(-8) M) for 60 min. The levels of aldosterone in plasma and medium were measured by radioimmunoassay. Cell lysates were analyzed by immunoblotting assay. After exercise and lactate infusion, plasma levels of aldosterone and lactate were significantly higher than those in the control group. Swimming for 10 min significantly increased the plasma Ang II levels in male rats. Administration of lactate plus Ang II significantly increased aldosterone production and enhanced protein expression of steroidogenic acute regulatory protein (StAR) in ZG cells. These results demonstrated that acute exercise led to the increase of both aldosterone and Ang II secretion, which is associated with lactate action on ZG cells and might be dependent on the activity of renin-angiotensin system.
關聯:	PLOS ONE 卷: 9 期: 10 文獻號碼: e87080
顯示於類別:	[化學工程與材料工程學系暨碩士班] 期刊論文

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