文化大學機構典藏 CCUR:Item 987654321/26660
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    题名: Glycated hemoglobin (HbA(1c)) affinity biosensors with ring-shaped interdigital electrodes on impedance measurement
    作者: Hsieh, KM (Hsieh, Ku-Meng)
    Lan, KC (Lan, Kung-Chieh)
    Hu, WL (Hu, Wei-Li)
    Chen, MK (Chen, Ming-Kun)
    Jang, LS (Jang, Ling-Sheng)
    Wang, MH (Wang, Min-Haw)
    贡献者: Dept Elect Engn
    关键词: Glycated hemoglobin (HbA(1c))
    Ring-shaped interdigital electrodes (RSIDEs)
    Thiophene-3-boronic acid (T3BA) Boronic
    Self-assembled monolayer (SAM)
    Capacitor biosensor
    Affinity
    Impedance measurement
    日期: 2013-11-15
    上传时间: 2014-02-21 15:02:10 (UTC+8)
    摘要: Abstract

    Glycated hemoglobin (HbA(1c)) is one of the most important diagnostic assays for the long-term mark of glycaemic control in diabetes. This study presents an affinity biosensor for HbA(1c) detection which is label-free based on the impedance measurement, and it features low cost, low sample volume, and requires no additional reagent in experiments. The ring-shaped interdigital electrodes (RSIDEs) are designed to promote the distribution uniformity and immobilization efficiency of HbA(1c), and are further employed to characterize the impedance change and identify various concentrations of HbA(1c). The self-assembled monolayer (SAM) of thiophene-3-boronic acid (T3BA) is provided to modify the gold electrode surface. Afterwards, the esterification reaction between HbA(1c), and T3BA produces a relative change of electrical property on the electrode surface. The RSIDEs with SAM of T3BA exhibit a wide range from 100 to 10 ng/mu L., producing an approximate logarithmic decrease of impedance, a low detection limit of 1 ng/mu L, a good selectivity and short-term stability for HbA(1c) determination. The remarkable advantages (miniaturization and low-cost) fill the bill of point-care diagnostics for portable sensor development. (C) 2013 Elsevier B.V. All rights reserved.
    關聯: BIOSENSORS & BIOELECTRONICS Volume: 49 Pages: 450-456
    显示于类别:[電機工程系] 期刊論文

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