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https://irlib.pccu.edu.tw/handle/987654321/2629
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| 題名: | Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea |
| 作者: | Shen, Chien-Chang
Wang, Yea-Hwey
Chang, Tun-Tschu
Lin, Lie-Chwen
Don, Ming-Jaw
Hou, Yu-Chang
Lious, Kuo-Tong
Chang, Shiou
Wang, Wen-Yen
Ko, Han-Chieh
Shen, Yuh-Chiang |
| 貢獻者: | 國術系 |
| 關鍵詞: | Polyporaceae
Antrodia salmonea
ergostane
lanostane
microglial cell
neutrophils
reactive oxygen species
nitric oxide (NO) |
| 日期: | 2007 |
| 上傳時間: | 2009-11-11 09:08:58 (UTC+8) |
| 摘要: | Three new anti-oxidative ergostanes, methyl antcinate L (1), antcin M (2), and methyl antcinate K (3), together with nine additional known compounds, 3-ketodehydrosulphurenic acid, sulphurenic acid, dehydrosulphurenic acid, 3 beta,15 alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid, zhankuic acid A, zhankuic acid B, zhankuic acid C, antcin C, and antcin K were isolated from the basidiomata of Antrodia salmonea, a newly identified species of Antrodia (Polyporaceae) in Taiwan. These three new compounds were identified as methyl 3 alpha,7 alpha,12 alpha-trihydroxy-4 alpha-methylergosta-8,24(29)-dien-11-on-26-oate (1), 3 alpha,12 alpha-dihydroxy-4 alpha-methylergosta-8,24(29)-dien-11-on-26-oic acid (2), and methyl 3 alpha,7 alpha,12 alpha-trihydroxy-4 alpha-methylergosta-8,24(29)-dien-11-on-26oate (3) by spectroscopic analysis. We studied their antioxidative potential on the production of reactive oxygen species and nitric oxide (NO) in neutrophils and microglial cells, respectively. Compounds 1-3 displayed potent antioxidative activity with IC50 values of around 2.0-8.8 MM that was partially due to inhibition (6-67 %) of NADPH oxidase activity but not through direct radical-scavenging properties. Compounds 1 - 3 also inhibited NO production with IC50 values of around 1.7-16.5 mu M and were more potent than a non-specific NOS inhibitor. We conclude that these three new compounds 1, 2, and 3 exhibit anti-inflammatory activities in activated inflammatory cells. |
| 關聯: | PLANTA MEDICA Volume: 73 Issue: 11 Pages: 1208-1213 |
| 顯示於類別: | [技擊運動暨國術學系] 期刊論文
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