Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells

文化大學機構典藏 CCUR > 環境規劃暨生物資源學院 > 農學院 > 園藝暨生物技術學系 > 期刊論文 > Item 987654321/24128

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題名:	Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells
作者:	Rao, YK (Rao, Yerra Koteswara) Lee, MJ (Lee, Meng-Jen) Chen, KR (Chen, Keru) Lee, YC (Lee, Yi-Ching) Wu, WS (Wu, Wen-Shi) Tzeng, YM (Tzeng, Yew-Min)
貢獻者:	Dept Hort & Biotechnol
關鍵詞:	FLAVONOID GLYCOSIDES METABOLIC SYNDROME GLUCOSE-TRANSPORT PROTEIN-KINASE PATHWAY THIAZOLIDINEDIONES TRANSLOCATION CONSTITUENTS ADIPOCYTES ACTIVATION
日期:	2011
上傳時間:	2013-01-31 14:33:10 (UTC+8)
摘要:	Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. Two flavone glycosides, rhoifolin and cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for rhoifolin (1.1%, w/w). In differentiated 3T3-L1 adipocytes, rhoifolin and cosmosiin showed dose-dependent response in concentration range of 0.001-5 mu M and 1-20 mu M, respectively, in biological studies beneficial to diabetes. Particularly, rhoifolin and cosmosiin at 0.5 and 20 mu M, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 mu M of rhoifolin and 20 mu M of cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-beta, in addition to their positive effect on GLUT4 translocation. These findings indicate that rhoifolin and cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-beta and GLUT4 translocation.
關聯:	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 頁數: 1-9
顯示於類別:	[園藝暨生物技術學系] 期刊論文

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