D-異抗壞血酸、L-抗壞血酸鈉、異抗壞血酸鈉、抗壞血酸鈣抗氧化劑於超臨界二氧化碳中之溶解度量測

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Title:	D-異抗壞血酸、L-抗壞血酸鈉、異抗壞血酸鈉、抗壞血酸鈣抗氧化劑於超臨界二氧化碳中之溶解度量測
Authors:	黃立明
Contributors:	化學工程與材料工程學系
Keywords:	抗氧化劑 Antioxidant 超臨界二氧化碳 Supercritical Carbon Dioxide Chrastil 模型 Chrastil model MST 模型 MST model 平均絕對相對偏差 Average absolute relative deviation
Date:	2012
Issue Date:	2012-10-11 09:11:59 (UTC+8)
Abstract:	本研究利用一半流動式超臨界實驗設備，量測四種抗氧化劑固體於超臨界二氧化碳中之溶解度。這四種抗氧化劑分別是L-抗壞血酸鈉(y2)、D-異抗壞血酸(y3)、異抗壞血酸鈉 (y4)及抗壞血酸鈣(y5)。實驗的溫度為308.15K、313.15K、318.15K而壓力範圍為12到24MPa之間。實驗結果顯示，L-抗壞血酸鈉(y2)、異抗壞血酸鈉 (y4)及抗壞血酸鈣(y5)的溶解度範圍均在10-7到10-8，而D-異抗壞血酸(y3) 的溶解度範圍在10-6到10-7。同時，本研究也利用兩條半經驗式MST Model和Chrastil Model，進行溶解度數據的回歸，並經由平均絕對相對偏差(AARD)來判斷實驗結果的合理性，由結果顯示4個藥品的AARD均小於5%。 In this study, we using a semi-flow type apparatus measure the solid solubility for four antioxidants in Supercritical carbon dioxide. These four antioxidants we used are Sodium L-ascorbic (y2), D-Isoascorbic acid9 (y3), Sodium Isoascorbate monohydrate(y4), Calcium L-ascorbate dehydrate (y5), respectively. The experimental data were taken at 308.15, 31315K and 318.15 K, over the pressure range from 12 to 24 MPa. The solubility of Sodium L-ascorbic (y2), Sodium Isoascorbate monohydrate(y4), Calcium L-ascorbate dehydrate (y5) are about 10-7 to 10-8 and D-Isoascorbic acid9 (y3) are about 10-6 to 10-7. The measured results were then correlated using semi-empirical equation presented by Chrastil and Mendez-Santiago and Teja. With optimally fitted parameters, these two equations yielded satisfactory results where the average absolute relative deviation (AARD) was below 5%.
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