Resveratrol Protects Left Ventricle by Increasing Adenylate Kinase 1 and Isocitrate Dehydrogenase Activities in Rats with Myocardial Infarction

文化大學機構典藏 CCUR > 理工學院 > 理學院 > 生命科學系 > 期刊論文 > Item 987654321/22902

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/22902

题名:	Resveratrol Protects Left Ventricle by Increasing Adenylate Kinase 1 and Isocitrate Dehydrogenase Activities in Rats with Myocardial Infarction
作者:	Lin, Jeng-Feng Wu, Semon Huang, Shiang-Suo Lu, Bo-Yi Lin, Su-Man Tsai, Shen-Kou
贡献者:	生命科學系
关键词:	ISCHEMIA-REPERFUSION INJURY HEART-FAILURE OXIDATIVE DAMAGE DYSFUNCTION SURVIVAL IMPROVES PHOSPHOTRANSFER ENERGETICS DISEASE TRIAL
日期:	2011-12-31
上传时间:	2012-08-30 14:44:18 (UTC+8)
摘要:	Our prior study had shown that resveratrol was a potent cardioprotective agent in rats with myocardial infarction (MI). In this study, we further evaluated the mechanism of cardioprotection of resveratrol by proteomic analysis. After permanent ligation of the left anterior descending artery under isoflurane anesthesia, surviving rats were randomly allocated to three groups and treated with resveratrol at 1 mg/kg/day (MI/R group), or vehicles (sham group and MI group) once daily for four weeks. In proteomic analysis, the MI group showed decreased expression of adenylate kinase 1 (AK1) and mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) after MI compared with the sham group. These variations were reversed by resveratrol in the MI/R group. Validation with Western blot and immunohistochemical analyses showed similar trends in protein expression profiling. Our studies suggest that the beneficial effects of resveratrol on ventricular modeling may be due to increased expression of AK1 and IDPm, which have been known to increase myocardial energetic efficiency and reduce reactive oxygen species-mediated damage, respectively.
關聯:	CHINESE JOURNAL OF PHYSIOLOGY Volume: 54 Issue: 6 Pages: 406-412
显示于类别:	[生命科學系] 期刊論文

文件中的档案:

没有与此文件相关的档案.

检视Licence

在CCUR中所有的数据项都受到原著作权保护.

数据加载中.....