阻力運動強度對肥胖男性脂締素及血管內皮功能的影響

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Title:	阻力運動強度對肥胖男性脂締素及血管內皮功能的影響 Effects of Intensity of Resistance Exercise on Plasma Adiponectin and Endothelial Function among Obesity Males
Authors:	林正常
Contributors:	運教所
Keywords:	心血管風險因子一氧化氮動脈硬化程度胰島素
Date:	2011~2012
Issue Date:	2012-02-23 11:00:08 (UTC+8)
Abstract:	阻力運動強度對肥胖男性脂締素及血管內皮功能的影響摘要背景：脂締素是由脂肪組織所產生的荷爾蒙，參與醣類及脂肪代謝功能的調節與抑制發炎反應，與肥胖、胰島素阻抗有極密切的關係。肥胖者是代謝異常、胰島素阻抗及內皮細胞功能損傷的潛在族群。阻力運動使肌肉收縮以及能量消耗，會引起代謝、內分泌及心血管功能等生理恆定狀態的改變。然而有不少研究指出長期阻力訓練會增加動脈硬化程度的負面效果，但阻力訓練卻也是美國運動醫學會對成人健康促進的建議運動項目，並能增進胰島素敏感度及代謝功能。阻力運動對動脈硬化、內分泌及代謝的立即影響仍尚未清楚。目的：探討單次等作功量不同強度阻力運動對肥胖男性血液脂締素濃度及血管內皮功能與心跳變異率的影響，以釐清阻力運動強度對心血管功能的立即效益。方法：將招募18名肥胖男性（18-24歲），分別進行等量單次低（40% 1RM，反覆12次，共進行3組，每組休息90秒）、中（60% 1RM，反覆8次，共進行3組，每組休息90秒）、高強度（80% 1RM，反覆6次，共進行3組，每組休息90秒）阻力運動，每次的阻力運動皆間隔2週，分析每次運動前後血液葡萄糖、胰島素阻抗、脂締素及血中一氧化氮濃度、胰島素阻抗程度以及運動前後脈波傳導速度 (PWV)、足踝上臂血壓比 (ABI) 及心跳變異率。 Effects of Intensity of Resistance Exercise on Plasma Adiponectin and Endothelial Function among Obesity Males Abstract Background: Adiponectin is a kind of hormones secreted from adipose tissues, involves in modulating the metabolic functions of carbohydrate, lipid and inflammatory responses. There are closely relationships between adiponectin, obesity and insulin resistance. Obesity people are the potential population of metabolic dysfunction, insulin resistance and endothelial dysfunction. Resistance exercise induces muscle contraction and energy expenditure, and disrupts homeostasis of metabolism, endocrine and cardiovascular function. However, many researchers suggested that long term resistance training would increase arterial stiffness, but resistance training also is a kind of exercise which ACSM suggested. Resistance training also enhance insulin sensitivity and metabolic function, but it is unclear that the effects of acute resistance exercise on arterial stiffness, endocrine, and metabolism. Purpose: To investigate the effects of acute resistance exercise with different intensity on plasma adiponectin, endothelial function and heart rate variability. Methods: This study will recruit 18 obesity males (18-24 yrs). They will proceed acute low (40% 1RM, 12 repetitions, 3 sets, resting 90s between each set), moderate (60% 1RM, 8 repetitions, 3 sets, resting 90s between each set), and high (80% 1RM, 6 repetitions, 3 sets, resting 90s between each set) intensity resistance exercise of equal work, and rest 2 weeks between each exercise trail. The responses of plasma adiponectin and nitric oxide concentrations, insulin resistance, pulse wave velocity (PWV) and ankle-brachial pressure index (ABI) will be analyzed before and after exercise.
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