高地訓練是競技選手在重要比賽前的熱門訓練方式。近年來人工低氧艙的發明，節省了傳統高地訓練費時費力的缺點，許多研究以人工低氧艙進行間歇式低氧訓練（Intermittent Hypoxic Training, IHT），亦有正面效果出現。然而，低氧環境曝露時間長短與運動強度的搭配，效果目前似乎未有定論。低氧誘發因子-1（HIF-1）為體內調節血管內皮生長因子（VEGF）重要環節，低氧環境造成人體細胞缺氧狀態，有可能促進血管內皮細胞修補作用。因此，本研究目的在透過不同組合之IHT，研究坐式生活型態者的心血管危險因子的訓練效果。方法：招募20 歲以上無規律運動習慣、BMI 大於25 以上或體脂率大於30％以上者共30 名男性。將通過篩選條件的受試者分為三組，氧氣相對濃度16％組、14％組、對照組(正常氧氣濃度20.70-20.93％)，並於訓練前進行基本心肺適能與血液生化檢驗。人工常壓低氧艙以個人50％V ‧ O2max 運動強度執行健走運動30 分鐘與動態恢復30 分鐘，共計60 分鐘。每週三次健走運動訓練，共 12 週。於訓練期第3、6、9、12 週與訓練後第1、3 週，進行攝氧量測試與採血檢驗。以混合設計二因子變異數分析法比較各組訓練前、訓練期第3、6、9、12 週結束與追蹤期第1、3 週時，在最大攝氧量、血管內生長因子、總膽固醇、三酸甘油酯數據之差異。本研究期能找出較適切的IHT 模式。
Altitude training is a popular conditioning method for athletes to improve endurance performance. Recently, many researches indicated intermittent hypoxic training (IHT) could increase athlete performance by economical and time-efficient artificial hypoxic chamber. However, the proper IHT duration and intensity are still a mystery. Hypoxia inducible factor-1(HIF-1) regulated vascular endothelial growth factor (VGEF) to induce vascular reparation process under hypoxia environment. Purpose: to investigate the influence of intermittent hypoxic training on sedentary people with cardiovascular risk factors by artificial hypoxic chamber. Methods: 30 sedentary lifestyle males characteristic of high BMI (>25%) or body fat percentage (>30%), divided into three groups i.e. FIO2 16%, FIO2 14% and control (20.70-20.93%) groups. All subjects requiredV ‧ O2max test and blood routine examination before IHT training. IHT protocol will be set at 50%V ‧ O2max of brisk walking on treadmill for 30 minutes then followed by a 30 minutes of cool down period, 3 times a week for total 12 weeks. There are 6 times ofV ‧ O2max tests and blood routine examinations performed at the end of 3rd, 6th, 9th and 12th week during IHT training, and 1st and 3rd week post-training, respectively. The mix-designed two-wayANOVA method will be applied to compare the difference among three groups forV ‧ O2max, VEGF, total cholesterol and triglycerides.We expect to find a better artificial IHT training module at the conclusion of this research.
